A decade after his heroic defeat of the monstrous Kraken, Perseus (Sam Worthington) is attempting to live a quieter life as a village fisherman and the sole parent to his 10-year-old son, Helius. Meanwhile, a struggle for supremacy rages between the gods and the Titans. Dangerously weakened by humanity's lack of devotion, the gods are losing control of the imprisoned Titans led by Kronos: father of the long-ruling brothers Zeus (Liam Neeson), Hades (Ralph Fiennes), and Poseidon (Danny Huston). The triumvirate had overthrown their powerful father long ago, leaving him to rot in the gloomy abyss of Tartarus, a dungeon that lies deep within the cavernous underworld.
Perseus cannot ignore his true calling when Hades and Ares (Édgar Ramírez) make a deal with Kronos to capture Zeus. The Titans' strength grows as Zeus's remaining godly powers are siphoned, and hell is unleashed on earth. Enlisting the help of the warrior QueenAndromeda (Rosamund Pike), Poseidon's demigod son Agenor (Toby Kebbell), and fallen god Hephaestus (Bill Nighy), Perseus bravely embarks on a treacherous quest into the underworld to rescue Zeus, overthrow the Titans and save mankind